Autosomal dominant polycystic kidney disease

ADPKD Most Common

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. About 12.5 million people worldwide and is the cause of 10% of End-Stage Kidney Disease (ESRD) that requires dialysis. It is the most common hereditary disorder that affects the kidney

Parent to Child

It's passed to 50% of the children from an affected parent. Polycystic means 'many cysts' and, for those with the disease, their kidneys can become very large and have a bumpy surface made of fluid-filled cysts.

Inherited and Family Testing

When cysts expand, this causes pressure to the kidney tissue which, may lead to end-stage kidney failure.

For those with the disease by their mid 40's dialysis and or transplantation are often required. Remember that kidney function decline is different in each person with ADPKD. Important to remember to have your blood pressure and overall health followed closely by your doctor.

Since this is inherited, people with the disease should seek advice in informing and testing family members who may be affected.

Seek Advice

Your social worker can advise you regarding the implications of life insurance and private insurance.

Kidney-Friendly Foods

Nutrition is important for everyone and eating a kidney-friendly diet for those that have ADPKD may help slow growth of cysts and slow the course of kidney function decline. 

MRI of the abdomen in the transaxial plane showing polycystic kidney disease.

What Are the Most Common Complications of ADPKD?

Those that suffer with ADPKD have pain, high blood pressure, and kidney failure at some point in their lives.

Pain

Pain is a common complication of ADPKD and is usually due to kidney or liver cysts. Pain also can be caused by

  • kidney cyst infection
  • bleeding or burst kidney cysts
  • urinary tract infection
  • kidney stones
  • tissue stretching around the kidney due to cyst growth

Additional side effects of ADPKD includes high blood pressure, edema, acidosis, heart health, stroke and kidney stones.  

Controlling your blood pressure can slow the effects of ADPKD. 


Lifestyle changes and medicines can lower high blood pressure along with a healthy diet and regular exercise. 

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Common Causes

Uremia

A serious complication of chronic kidney disease or kidney injury.

Common Causes

Urinary Tract Infection

Damage can occur if there is an obstruction or blockage of urine.

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Symptoms & Signs

Spot the warning signs and often silent symptoms of kidney disease.